DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase.

4'-Thio-2'-deoxycytidine was synthesized as a 5'- protected phosphoramidite compatible with solid phase DNA synthesis. When incorporated as the target cytosine (C*) in the GC*GC recognition sequence for the DNA methyltransferase M. HhaI, methyl transfer was strongly inhibited. In contrast, these sam...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Kumar, S, Horton, J R, Jones, G D, Walker, R T, Roberts, R J, Cheng, X
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146812/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207024/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.14.2773
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