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SUMO-Interacting Motifs of Human TRIM5α are Important for Antiviral Activity

Human TRIM5α potently restricts particular strains of murine leukemia viruses (the so-called N-tropic strains) but not others (the B- or NB-tropic strains) during early stages of infection. We show that overexpression of SUMO-1 in human 293T cells, but not in mouse MDTF cells, profoundly blocks N-ML...

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Sonraí Bibleagrafaíochta
Main Authors: Arriagada, Gloria, Muntean, Lucia N., Goff, Stephen P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3072370/
https://ncbi.nlm.nih.gov/pubmed/21490953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002019
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