The Antiviral Spectra of TRIM5α Orthologues and Human TRIM Family Proteins against Lentiviral Production

BACKGROUND: Rhesus monkey TRIM5α (TRIM5αrh) recognizes the incoming HIV-1 core through its C-terminal B30.2(PRYSPRY) domain and promotes its premature disassembly or degradation before reverse transcription. Previously, we have shown that TRIM5αrh blocks HIV-1 production through the N-terminal RBCC...

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Bibliographic Details
Main Authors: Ohmine, Seiga, Sakuma, Ryuta, Sakuma, Toshie, Thatava, Tayaramma, Takeuchi, Hiroaki, Ikeda, Yasuhiro
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021539/
https://ncbi.nlm.nih.gov/pubmed/21264255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016121
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