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SUMO-Interacting Motifs of Human TRIM5α are Important for Antiviral Activity
Human TRIM5α potently restricts particular strains of murine leukemia viruses (the so-called N-tropic strains) but not others (the B- or NB-tropic strains) during early stages of infection. We show that overexpression of SUMO-1 in human 293T cells, but not in mouse MDTF cells, profoundly blocks N-ML...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3072370/ https://ncbi.nlm.nih.gov/pubmed/21490953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002019 |
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