Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41

Here, we describe the genetic pathways taken by a human immunodeficiency virus type 1 (HIV-1) isolate, D101.12, to become resistant to the small molecule CCR5 inhibitor, vicriviroc (VCV) in vitro. Resistant D101.12 variants contained at least one substitution in the gp120 V3 region (H308P), plus one...

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Main Authors: Anastassopoulou, Cleo G., Ketas, Thomas J., Depetris, Rafael S., Thomas, Antonia M., Klasse, Per Johan, Moore, John P.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3070043/
https://ncbi.nlm.nih.gov/pubmed/21356539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.12.052
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