Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41

We have investigated the mechanism of resistance of a HIV type 1 (HIV-1) R5 primary isolate, D1/85.16, to the small molecule CCR5 inhibitor, vicriviroc (VVC). Unlike other viruses resistant to this class of compound, D1/85.16 lacks sequence changes in the V3 region of the gp120 surface glycoprotein....

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Detaylı Bibliyografya
Asıl Yazarlar: Anastassopoulou, Cleo G., Ketas, Thomas J., Klasse, Per Johan, Moore, John P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2009
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664029/
https://ncbi.nlm.nih.gov/pubmed/19289833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811713106
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