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Resistance to CCR5 inhibitors caused by sequence changes in the fusion peptide of HIV-1 gp41
We have investigated the mechanism of resistance of a HIV type 1 (HIV-1) R5 primary isolate, D1/85.16, to the small molecule CCR5 inhibitor, vicriviroc (VVC). Unlike other viruses resistant to this class of compound, D1/85.16 lacks sequence changes in the V3 region of the gp120 surface glycoprotein....
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2664029/ https://ncbi.nlm.nih.gov/pubmed/19289833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811713106 |
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