Inefficient entry of vicriviroc-resistant HIV-1 via the inhibitor-CCR5 complex at low cell surface CCR5 densities

HIV-1 variants resistant to small molecule CCR5 inhibitors such as vicriviroc (VVC) have modified Env complexes that can use both the inhibitor-bound and -free forms of the CCR5 co-receptor to enter target cells. However, entry via the inhibitor-CCR5 complex is inefficient in some, but not all, cell...

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Autors principals: Pugach, Pavel, Ray, Neelanjana, Klasse, Per Johan, Ketas, Thomas J., Michael, Elizabeth, Doms, Robert W., Lee, Benhur, Moore, John P.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674391/
https://ncbi.nlm.nih.gov/pubmed/19303620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2009.02.044
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