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V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc
HIV-1 develops resistance to CCR5 antagonists such as Maraviroc (MVC) and Vicriviroc (VVC) both in vitro and in vivo, with most changes arising in the gp120 V3 region. Both compounds bind to the same hydrophobic cavity in CCR5 in subtly different ways. Here, we investigated which V3 sequence changes...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3320651/ https://ncbi.nlm.nih.gov/pubmed/22424737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.02.006 |
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