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V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc

HIV-1 develops resistance to CCR5 antagonists such as Maraviroc (MVC) and Vicriviroc (VVC) both in vitro and in vivo, with most changes arising in the gp120 V3 region. Both compounds bind to the same hydrophobic cavity in CCR5 in subtly different ways. Here, we investigated which V3 sequence changes...

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書誌詳細
主要な著者: Berro, Reem, Klasse, Per Johan, Moore, John P., Sanders, Rogier W.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320651/
https://ncbi.nlm.nih.gov/pubmed/22424737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.02.006
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