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Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance
A rare pathway of HIV-1 resistance to small molecule CCR5 inhibitors such as Vicriviroc (VCV) involves changes solely in the gp41 fusion peptide (FP). Here, we show that the G516V change is critical to VCV resistance in PBMC and TZM-bl cells, although it must be accompanied by either M518V or F519I...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3353024/ https://ncbi.nlm.nih.gov/pubmed/22520838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.03.008 |
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