Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance

A rare pathway of HIV-1 resistance to small molecule CCR5 inhibitors such as Vicriviroc (VCV) involves changes solely in the gp41 fusion peptide (FP). Here, we show that the G516V change is critical to VCV resistance in PBMC and TZM-bl cells, although it must be accompanied by either M518V or F519I...

Full description

Saved in:
Bibliographic Details
Main Authors: Anastassopoulou, Cleo G., Ketas, Thomas J., Sanders, Rogier W., Klasse, Per Johan, Moore, John P.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353024/
https://ncbi.nlm.nih.gov/pubmed/22520838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.03.008
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items