Φορτώνει......
Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41
Here, we describe the genetic pathways taken by a human immunodeficiency virus type 1 (HIV-1) isolate, D101.12, to become resistant to the small molecule CCR5 inhibitor, vicriviroc (VCV) in vitro. Resistant D101.12 variants contained at least one substitution in the gp120 V3 region (H308P), plus one...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3070043/ https://ncbi.nlm.nih.gov/pubmed/21356539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.12.052 |
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