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Potent Strategy To Inhibit HIV-1 by Binding both gp120 and gp41

The development of an anti-HIV microbicide is critical in the fight against the spread of HIV. It is shown here that the covalent linking of compounds that bind gp120 with compounds that bind gp41 can inhibit HIV entry even more potently than individual inhibitors or noncovalent combinations. The mo...

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Detalhes bibliográficos
Main Authors: Kagiampakis, Ioannis, Gharibi, Arbi, Mankowski, Marie K., Snyder, Beth A., Ptak, Roger G., Alatas, Kristabelle, LiWang, Patricia J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019634/
https://ncbi.nlm.nih.gov/pubmed/20956603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00376-10
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