Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions with the Coreceptor

Antzeko izenburuak

• Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120
  nork: Derdeyn, Cynthia A., et al.
  Argitaratua: (2000)
• Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket
  nork: Yu, Xiaowen, et al.
  Argitaratua: (2012)
• Mutations That Increase the Stability of the Postfusion gp41 Conformation of the HIV-1 Envelope Glycoprotein Are Selected by both an X4 and R5 HIV-1 Virus To Escape Fusion Inhibitors Corresponding to Heptad Repeat 1 of gp41, but the gp120 Adaptive Mutations Differ between the Two Viruses
  nork: Zhuang, Min, et al.
  Argitaratua: (2019)
• A Functional Interaction between gp41 and gp120 Is Observed for Monomeric but Not Oligomeric, Uncleaved HIV-1 Env gp140
  nork: Guttman, Miklos, et al.
  Argitaratua: (2013)
• Potent Strategy To Inhibit HIV-1 by Binding both gp120 and gp41
  nork: Kagiampakis, Ioannis, et al.
  Argitaratua: (2011)