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Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions with the Coreceptor

T-20 is a synthetic peptide that corresponds to 36 amino acids within the C-terminal heptad repeat region (HR2) of human immunodeficiency virus type 1 (HIV-1) gp41. T-20 has been shown to potently inhibit viral replication of HIV-1 both in vitro and in vivo and is currently being evaluated in a Phas...

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Udgivet i:J Virol
Principais autores: Derdeyn, Cynthia A., Decker, Julie M., Sfakianos, Jeffrey N., Zhang, Zhijun, O'Brien, William A., Ratner, Lee, Shaw, George M., Hunter, Eric
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115106/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11507206/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.18.8605-8614.2001
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