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The Griffithsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Griffithsin Dimer Mechanism

Griffithsin (Grft) is a protein lectin derived from red algae that tightly binds the HIV envelope protein gp120 and effectively inhibits virus infection. This inhibition is due to the binding by Grft of high-mannose saccharides on the surface of gp120. Grft has been shown to be a tight dimer, but th...

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Main Authors: Xue, Jie, Hoorelbeke, Bart, Kagiampakis, Ioannis, Demeler, Borries, Balzarini, Jan, LiWang, Patricia J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719714/
https://ncbi.nlm.nih.gov/pubmed/23752505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00332-13
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