Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells

Oncolytic adenoviruses replicate selectively within and lyse malignant cells. As such, they are being developed as anticancer therapeutics. However, the sensitivity of ovarian cancers to adenovirus cytotoxicity varies greatly, even in cells of similar infectivity. Using both the adenovirus E1A-CR2 d...

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Hlavní autoři: Connell, Claire M., Shibata, Atsushi, Tookman, Laura A., Archibald, Kyra M., Flak, Magdalena B., Pirlo, Katrina J., Lockley, Michelle, Wheatley, Sally P., McNeish, Iain A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069766/
https://ncbi.nlm.nih.gov/pubmed/21383502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43976
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