Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells

Oncolytic adenoviruses replicate selectively within and lyse malignant cells. As such, they are being developed as anticancer therapeutics. However, the sensitivity of ovarian cancers to adenovirus cytotoxicity varies greatly, even in cells of similar infectivity. Using both the adenovirus E1A-CR2 d...

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Detalhes bibliográficos
Main Authors: Connell, Claire M., Shibata, Atsushi, Tookman, Laura A., Archibald, Kyra M., Flak, Magdalena B., Pirlo, Katrina J., Lockley, Michelle, Wheatley, Sally P., McNeish, Iain A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069766/
https://ncbi.nlm.nih.gov/pubmed/21383502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43976
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