Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells

Oncolytic adenoviruses replicate selectively within and lyse malignant cells. As such, they are being developed as anticancer therapeutics. However, the sensitivity of ovarian cancers to adenovirus cytotoxicity varies greatly, even in cells of similar infectivity. Using both the adenovirus E1A-CR2 d...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Connell, Claire M., Shibata, Atsushi, Tookman, Laura A., Archibald, Kyra M., Flak, Magdalena B., Pirlo, Katrina J., Lockley, Michelle, Wheatley, Sally P., McNeish, Iain A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069766/
https://ncbi.nlm.nih.gov/pubmed/21383502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43976
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares