RAD51 and BRCA2 enhance oncolytic adenovirus type 5 activity in ovarian cancer

Homologous Recombination (HR) function is critically important in High Grade Serous Ovarian Cancer (HGSOC). HGSOC with intact HR has a worse prognosis and is less likely to respond to platinum chemotherapy and PARP inhibitors. Oncolytic adenovirus, a novel therapy for human malignancies, stimulates...

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Detalhes bibliográficos
Publicado no:Mol Cancer Res
Main Authors: Tookman, Laura A., Browne, Ashley K., Connell, Claire M., Bridge, Gemma, Ingemarsdotter, Carin K., Dowson, Suzanne, Shibata, Atsushi, Lockley, Michelle, Martin, Sarah A., McNeish, Iain A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716290/
https://ncbi.nlm.nih.gov/pubmed/26452665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-15-0188-T
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