Paclitaxel resistance increases oncolytic adenovirus efficacy via upregulated CAR expression and dysfunctional cell cycle control

Resistance to paclitaxel chemotherapy frequently develops in ovarian cancer. Oncolytic adenoviruses are a novel therapy for human malignancies that are being evaluated in early phase trials. However, there are no reliable predictive biomarkers for oncolytic adenovirus activity in ovarian cancer. We...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Ingemarsdotter, Carin K., Tookman, Laura A., Browne, Ashley, Pirlo, Katrina, Cutts, Rosalind, Chelela, Claude, Khurrum, Karisma F., Leung, Elaine Y.L., Dowson, Suzanne, Webber, Lee, Khan, Iftekhar, Ennis, Darren, Syed, Nelofer, Crook, Tim R., Brenton, James D., Lockley, Michelle, McNeish, Iain A.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2014
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528770/
https://ncbi.nlm.nih.gov/pubmed/25560085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2014.12.007
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