Inhibition of the Inflammatory Cytokine TNF-α Increases Adenovirus Activity in Ovarian Cancer via Modulation of cIAP1/2 Expression

Oncolytic adenoviruses show promise as a cancer treatment. However, they generate acute inflammatory responses with production of cytokines, including tumor necrosis factor-α (TNF-α). We investigated whether inhibition of TNF-α augments efficacy of the E1A CR2-deleted adenovirus dl922-947 in ovarian...

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Detalhes bibliográficos
Main Authors: Salako, Michael A, Kulbe, Hagen, Ingemarsdotter, Carin K, Pirlo, Katrina J, Williams, Sarah L, Lockley, Michelle, Balkwill, Frances R, McNeish, Iain A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048177/
https://ncbi.nlm.nih.gov/pubmed/21081903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.247
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