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Pharmacological inhibition of β3 integrin reduces the inflammatory toxicities caused by oncolytic adenovirus without compromising anticancer activity

Adenoviruses have been clinically tested as anti-cancer therapies but their utility has been severely limited by rapid, systemic cytokine release and consequent inflammatory toxicity. Here we describe a new approach to tackling these dangerous side effects. Using human ovarian cancer cell lines as w...

詳細記述

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書誌詳細
出版年:Cancer Res
主要な著者: Browne, Ashley, Tookman, Laura A., Ingemarsdotter, Carin K., Bouwman, Russell D., Pirlo, Katrina, Wang, Yaohe, McNeish, Iain A., Lockley, Michelle
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506788/
https://ncbi.nlm.nih.gov/pubmed/25977332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-3761
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