Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells

Oncolytic adenoviruses replicate selectively within and lyse malignant cells. As such, they are being developed as anticancer therapeutics. However, the sensitivity of ovarian cancers to adenovirus cytotoxicity varies greatly, even in cells of similar infectivity. Using both the adenovirus E1A-CR2 d...

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Détails bibliographiques
Auteurs principaux: Connell, Claire M., Shibata, Atsushi, Tookman, Laura A., Archibald, Kyra M., Flak, Magdalena B., Pirlo, Katrina J., Lockley, Michelle, Wheatley, Sally P., McNeish, Iain A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2011
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069766/
https://ncbi.nlm.nih.gov/pubmed/21383502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43976
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