Failure of Translation of Human Adenovirus mRNA in Murine Cancer Cells Can be Partially Overcome by L4-100K Expression In Vitro and In Vivo

Adaptive immune responses may be vital in the overall efficacy of oncolytic viruses in human malignancies. However, immune responses to oncolytic adenoviruses are poorly understood because these viruses lack activity in murine cells, which precludes evaluation in immunocompetent murine cancer models...

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Detalhes bibliográficos
Main Authors: Young, Anna-Mary, Archibald, Kyra M, Tookman, Laura A, Pool, Alexander, Dudek, Kate, Jones, Carolyn, Williams, Sarah L, Pirlo, Katrina J, Willis, Anne E, Lockley, Michelle, McNeish, Iain A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437579/
https://ncbi.nlm.nih.gov/pubmed/22735379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.116
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