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PDE4D and PDE4B Function in Distinct Subcellular Compartments in Mouse Embryonic Fibroblasts

Signaling through cAMP regulates most cellular functions. The spatiotemporal control of cAMP is, therefore, crucial for differential regulation of specific cellular targets. Here we investigated the consequences of PDE4B or PDE4D gene ablation on cAMP signaling at a subcellular level using mouse emb...

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Hlavní autoři: Blackman, Brigitte E., Horner, Kathleen, Heidmann, Julia, Wang, Dan, Richter, Wito, Rich, Thomas C., Conti, Marco
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069460/
https://ncbi.nlm.nih.gov/pubmed/21288894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.203604
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