Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

siRNAs confer sequence specific and robust silencing of mRNA. By virtue of these properties, siRNAs have become therapeutic candidates for disease intervention. However, their use as therapeutic agents can be hampered by unintended off-target effects by either or both strands of the siRNA duplex. We...

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Detalhes bibliográficos
Main Authors: Vaish, Narendra, Chen, Feng, Seth, Shaguna, Fosnaugh, Kathy, Liu, Yan, Adami, Roger, Brown, Tod, Chen, Yan, Harvie, Pierrot, Johns, Rachel, Severson, Gregory, Granger, Brian, Charmley, Patrick, Houston, Michael, Templin, Michael V., Polisky, Barry
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061082/
https://ncbi.nlm.nih.gov/pubmed/21047800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq961
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