An Amino Acid-based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA

We demonstrate a systematic and rational approach to create a library of natural and modified, dialkylated amino acids based upon arginine for development of an efficient small interfering RNA (siRNA) delivery system. These amino acids, designated DiLA(2) compounds, in conjunction with other compone...

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Detalhes bibliográficos
Main Authors: Adami, Roger C, Seth, Shaguna, Harvie, Pierrot, Johns, Rachel, Fam, Renata, Fosnaugh, Kathy, Zhu, Tianying, Farber, Ken, McCutcheon, Michael, Goodman, Thomas T, Liu, Yan, Chen, Yan, Kwang, Erin, Templin, Michael V, Severson, Greg, Brown, Tod, Vaish, Narendra, Chen, Feng, Charmley, Patrick, Polisky, Barry, Houston, Michael E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129796/
https://ncbi.nlm.nih.gov/pubmed/21505423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.56
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