An Amino Acid-based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA

We demonstrate a systematic and rational approach to create a library of natural and modified, dialkylated amino acids based upon arginine for development of an efficient small interfering RNA (siRNA) delivery system. These amino acids, designated DiLA(2) compounds, in conjunction with other compone...

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Autores principales: Adami, Roger C, Seth, Shaguna, Harvie, Pierrot, Johns, Rachel, Fam, Renata, Fosnaugh, Kathy, Zhu, Tianying, Farber, Ken, McCutcheon, Michael, Goodman, Thomas T, Liu, Yan, Chen, Yan, Kwang, Erin, Templin, Michael V, Severson, Greg, Brown, Tod, Vaish, Narendra, Chen, Feng, Charmley, Patrick, Polisky, Barry, Houston, Michael E
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3129796/
https://ncbi.nlm.nih.gov/pubmed/21505423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.56
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