Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

siRNAs confer sequence specific and robust silencing of mRNA. By virtue of these properties, siRNAs have become therapeutic candidates for disease intervention. However, their use as therapeutic agents can be hampered by unintended off-target effects by either or both strands of the siRNA duplex. We...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Vaish, Narendra, Chen, Feng, Seth, Shaguna, Fosnaugh, Kathy, Liu, Yan, Adami, Roger, Brown, Tod, Chen, Yan, Harvie, Pierrot, Johns, Rachel, Severson, Gregory, Granger, Brian, Charmley, Patrick, Houston, Michael, Templin, Michael V., Polisky, Barry
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Oxford University Press 2011
Θέματα:
RNA
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061082/
https://ncbi.nlm.nih.gov/pubmed/21047800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq961
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