5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting

Optimization of small interfering RNAs (siRNAs) is important in RNA interference (RNAi)-based therapeutic development. Some specific chemical modifications can control which siRNA strand is selected by the RNA-induced silencing complex (RISC) for gene silencing. Intended strand selection will increa...

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Detalhes bibliográficos
Main Authors: Snead, Nicholas M, Escamilla-Powers, Julie R, Rossi, John J, McCaffrey, Anton P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732871/
https://ncbi.nlm.nih.gov/pubmed/23820891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.36
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