5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting

Optimization of small interfering RNAs (siRNAs) is important in RNA interference (RNAi)-based therapeutic development. Some specific chemical modifications can control which siRNA strand is selected by the RNA-induced silencing complex (RISC) for gene silencing. Intended strand selection will increa...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Snead, Nicholas M, Escamilla-Powers, Julie R, Rossi, John J, McCaffrey, Anton P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
Soggetti:
Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3732871/
https://ncbi.nlm.nih.gov/pubmed/23820891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.36
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi