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Triplex Hybridization of siRNA with Bifacial Glycopolymer Nucleic Acid Enables Hepatocyte-Targeted Silencing
Herein, we describe a versatile non-covalent strategy for packaging nucleic acid cargo with targeting modalities, based on triplex hybridization of oligo-uridylate RNA with bifacial polymer nucleic acid (bP(o)NA). Polyacrylate bP(o)NA was prepared and side chain-functionalized with N-acetylgalactosa...
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| Udgivet i: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001860/ https://ncbi.nlm.nih.gov/pubmed/31141333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.9b00273 |
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