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A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.
One form of multidrug resistance is due to the expression of a 170-kDa energy-dependent drug efflux pump called P-glycoprotein in the plasma membranes of human cancer cells. We have prepared conjugates of Pseudomonas toxin with the anti-P-glycoprotein monoclonal antibody MRK-16. These anti-P-glycopr...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1987
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3495806/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.12.4288 |
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