A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

One form of multidrug resistance is due to the expression of a 170-kDa energy-dependent drug efflux pump called P-glycoprotein in the plasma membranes of human cancer cells. We have prepared conjugates of Pseudomonas toxin with the anti-P-glycoprotein monoclonal antibody MRK-16. These anti-P-glycopr...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	FitzGerald, D J, Willingham, M C, Cardarelli, C O, Hamada, H, Tsuruo, T, Gottesman, M M, Pastan, I
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1987
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3495806/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.12.4288
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