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A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

One form of multidrug resistance is due to the expression of a 170-kDa energy-dependent drug efflux pump called P-glycoprotein in the plasma membranes of human cancer cells. We have prepared conjugates of Pseudomonas toxin with the anti-P-glycoprotein monoclonal antibody MRK-16. These anti-P-glycopr...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: FitzGerald, D J, Willingham, M C, Cardarelli, C O, Hamada, H, Tsuruo, T, Gottesman, M M, Pastan, I
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305070/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3495806/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.12.4288
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