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Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes.

Pseudomonas exotoxin (PE) is a protein toxin composed of three structural domains. In its native form, the toxin is a 66,000-Mr proenzyme that must be activated to express full ADP-ribosylating activity. To study the process of activation and accompanying conformational changes, we have isolated 10...

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Bibliographic Details
Main Authors: Ogata, M, Pastan, I, FitzGerald, D
Format: Artigo
Language:Inglês
Published: 1991
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC257755/
https://ncbi.nlm.nih.gov/pubmed/1702764
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