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Analysis of Pseudomonas exotoxin activation and conformational changes by using monoclonal antibodies as probes.

Pseudomonas exotoxin (PE) is a protein toxin composed of three structural domains. In its native form, the toxin is a 66,000-Mr proenzyme that must be activated to express full ADP-ribosylating activity. To study the process of activation and accompanying conformational changes, we have isolated 10...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Infect Immun
Prif Awduron: Ogata, M, Pastan, I, FitzGerald, D
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 1991
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC257755/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1702764/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.59.1.407-414.1991
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