Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin.

Immunotoxins were made using five different murine monoclonal antibodies to the human erbB2 gene product and LysPE40, a 40-kDa recombinant form of Pseudomonas exotoxin (PE) lacking its cell-binding domain. All five conjugates were specifically cytotoxic to cancer cell lines overexpressing erbB2 prot...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Batra, J K, Kasprzyk, P G, Bird, R E, Pastan, I, King, C R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49398/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1352878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.13.5867
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