Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin.

LysPE40 is a modified form of Pseudomonas exotoxin that lacks the cell-binding domain and has a chemically reactive lysine residue near the amino terminus. LysPE40 is made in Escherichia coli and secreted into the medium from which it is readily purified. Two immunotoxins were constructed by couplin...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Batra, J K, Jinno, Y, Chaudhary, V K, Kondo, T, Willingham, M C, FitzGerald, D J, Pastan, I
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298319/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2510169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.21.8545
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