A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

One form of multidrug resistance is due to the expression of a 170-kDa energy-dependent drug efflux pump called P-glycoprotein in the plasma membranes of human cancer cells. We have prepared conjugates of Pseudomonas toxin with the anti-P-glycoprotein monoclonal antibody MRK-16. These anti-P-glycopr...

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Hauptverfasser: FitzGerald, D J, Willingham, M C, Cardarelli, C O, Hamada, H, Tsuruo, T, Gottesman, M M, Pastan, I
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1987
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC305070/
https://ncbi.nlm.nih.gov/pubmed/3495806
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