Inhibition of secreted phospholipases A(2) by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations

Group IIA secreted phospholipase A(2) (GIIA sPLA(2)) is a member of the mammalian sPLA(2) enzyme family and is associated with various inflammatory conditions. In this study, the synthesis of 2-oxoamides based on α-amino acids and the in vitro evaluation against three secreted sPLA(2)s (GIIA, GV and...

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Autores principales: Mouchlis, Varnavas D., Magrioti, Victoria, Barbayianni, Efrosini, Cermak, Nathan, Oslund, Rob C., Mavromoustakos, Thomas M., Gelb, Michael H., Kokotos, George
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050527/
https://ncbi.nlm.nih.gov/pubmed/21216150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.12.030
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