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Impaired insulin secretion in transgenic mice overexpressing calpastatin in pancreatic beta-cells

Calpains are a family of calcium-activated proteases involved in a number of cellular functions including cell death, proliferation and exocytosis. The finding that variation in the calpain-10 gene increases type 2 diabetes risk in some populations has increased interest in determining the potential...

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書目詳細資料
Main Authors: Johnson, James D., Otani, Kenichi, Bell, Graeme I., Polonsky, Kenneth S.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3044710/
https://ncbi.nlm.nih.gov/pubmed/21099278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/isl.1.3.9780
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