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Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.

Phosphorylation of glucose to glucose 6-phosphate by glucokinase (GK; EC 2.7.1.2) serves as a glucose-sensing mechanism for regulating insulin secretion in beta cells. Recent findings of heterozygous GK gene mutations in patients with maturity-onset diabetes of the young (MODY), a form of type II (n...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Efrat, S, Leiser, M, Wu, Y J, Fusco-DeMane, D, Emran, O A, Surana, M, Jetton, T L, Magnuson, M A, Weir, G, Fleischer, N
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1994
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43307/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7510884/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.6.2051
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