Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.

Phosphorylation of glucose to glucose 6-phosphate by glucokinase (GK; EC 2.7.1.2) serves as a glucose-sensing mechanism for regulating insulin secretion in beta cells. Recent findings of heterozygous GK gene mutations in patients with maturity-onset diabetes of the young (MODY), a form of type II (n...

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Main Authors: Efrat, S, Leiser, M, Wu, Y J, Fusco-DeMane, D, Emran, O A, Surana, M, Jetton, T L, Magnuson, M A, Weir, G, Fleischer, N
Format: Artigo
Sprog:Inglês
Udgivet: 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC43307/
https://ncbi.nlm.nih.gov/pubmed/7510884
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