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Diabetes induced in male transgenic mice by expression of human H-ras oncoprotein in pancreatic beta cells.
Transgenic mice expressing an insulin-promoted H-ras hybrid gene in pancreatic beta cells developed beta-cell degeneration and diabetes. The disease was manifested in male mice by hyperglycemia, glycosuria, and reduced plasma insulin levels, which appeared around 5 months of age and led to premature...
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| Publicado no: | Mol Cell Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362285/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2181284/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.4.1779 |
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