Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.

Overexpression of heavy chains of the class I major histocompatibility complex in islet beta cells of transgenic mice is known to induce nonimmune diabetes. We have now overexpressed the secretory protein beta 2-microglobulin in beta cells. Transgenic mice of one lineage had normal islets. Mice of a...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Allison, J, Malcolm, L, Culvenor, J, Bartholomeusz, R K, Holmberg, K, Miller, J F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC51170/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2006144/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.6.2070
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