Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.

Overexpression of heavy chains of the class I major histocompatibility complex in islet beta cells of transgenic mice is known to induce nonimmune diabetes. We have now overexpressed the secretory protein beta 2-microglobulin in beta cells. Transgenic mice of one lineage had normal islets. Mice of a...

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Main Authors: Allison, J, Malcolm, L, Culvenor, J, Bartholomeusz, R K, Holmberg, K, Miller, J F
Formato: Artigo
Idioma:Inglês
Publicado: 1991
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC51170/
https://ncbi.nlm.nih.gov/pubmed/2006144
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