HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

AIMS/HYPOTHESIS: Pancreatic beta cell dysfunction is a prerequisite for the development of type 2 diabetes. Histone deacetylases (HDACs) may affect pancreatic endocrine function and glucose homeostasis through alterations in gene regulation. Our aim was to investigate the role of HDAC7 in human and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Diabetologia
Main Authors: Daneshpajooh, Mahboubeh, Bacos, Karl, Bysani, Madhusudhan, Bagge, Annika, Ottosson Laakso, Emilia, Vikman, Petter, Eliasson, Lena, Mulder, Hindrik, Ling, Charlotte
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6518079/
https://ncbi.nlm.nih.gov/pubmed/27796421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-016-4113-2
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