Transgenic mice overexpressing human G972R IRS-1 show impaired insulin action and insulin secretion.

Molecular scanning of human insulin receptor substrate (Irs) genes revealed a single lrs1 prevalent variant, a glycine to arginine change at codon 972 (G972R); previous in vitro studies had demonstrated that the presence of this variant results in an impaired activation of the insulin signalling pat...

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Bibliographic Details
Published in:J Cell Mol Med
Main Authors: Hribal, Marta L, Tornei, F, Pujol, A, Menghini, R, Barcaroli, D, Lauro, D, Amoruso, R, Lauro, R, Bosch, F, Sesti, G, Federici, M
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506174/
https://ncbi.nlm.nih.gov/pubmed/18208559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2008.00246.x
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