Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance.

The hexosamine biosynthetic pathway has been hypothesized to be involved in mediating some of the toxic effects of hyperglycemia. Glutamine:fructose-6-phosphate amidotransferase (GFA), the first and rate limiting enzyme of the hexosamine biosynthetic pathway, was overexpressed in skeletal muscle and...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Hebert, L F, Daniels, M C, Zhou, J, Crook, E D, Turner, R L, Simmons, S T, Neidigh, J L, Zhu, J S, Baron, A D, McClain, D A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1996
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507507/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8770864/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118876
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