Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review

Abstract Glutamine: fructose-6-phosphate amidotransferase (GFAT), a conserved enzyme across prokaryotic and eukaryotic species, is the first and rate-limiting step in the hexosamine biosynthetic pathway (HBP), diverting 2–5% of fructose-6-phosphate derived from glucose toward the synthesis of uridin...

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Bibliografische Detailangaben

Hauptverfasser:	Caiting Yang, Fengyu Chu, Xiaoli Chen, Fanqi Meng, Yinhao Li, Jingwen Chen, Chaoyang Sun, Yahui Shang, Ruibin Guo, Jianming Wang, Changxin Wu, Huiping Duan, Miaomiao Shao, Wei Yuan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2025-12-01
Schriftenreihe:	Cell Death Discovery
Online-Zugang:	https://doi.org/10.1038/s41420-025-02898-8
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