TIMP3 Overexpression in Macrophages Protects From Insulin Resistance, Adipose Inflammation, and Nonalcoholic Fatty Liver Disease in Mice

The tissue inhibitor of metalloproteinase (TIMP)3, a stromal protein that restrains the activity of proteases and receptors, is reduced in inflammatory metabolic disorders such as type 2 diabetes mellitus (T2DM) and atherosclerosis. We overexpressed Timp3 in mouse macrophages (MacT3) to analyze its...

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Autori principali: Menghini, Rossella, Casagrande, Viviana, Menini, Stefano, Marino, Arianna, Marzano, Valeria, Hribal, Marta L., Gentileschi, Paolo, Lauro, Davide, Schillaci, Orazio, Pugliese, Giuseppe, Sbraccia, Paolo, Urbani, Andrea, Lauro, Renato, Federici, Massimo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2012
Soggetti:
Pathophysiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3266402/
https://ncbi.nlm.nih.gov/pubmed/22228717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0613
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